5. Pay Attention to Timing and Window of Opportunity
When both buffs and debuffs are applied, their timing and duration can greatly impact the course of the fight. Be mindful of Diablo 4 Items when these effects are most beneficial and act quickly when opportunities arise.

Buff Timing: Keep track of when certain buffs are about to expire, especially those that grant resource regeneration or reduced cooldowns. Make sure to reapply them at the right moment to avoid a gap in their effectiveness.

Debuff Timing: Apply damage-increasing debuffs right before unleashing your powerful abilities. For example, hitting an enemy with Vulnerability right before your ultimate ability will increase the damage output and help ensure that you use your resources effectively.

Window of Opportunity: During periods when the boss or Diablo IV Items for sale elite monster is stunned, incapacitated, or in an animation where they can’t attack, use this window to apply buffs, regen resources, or position yourself for a big combo attack.